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Moreover, exposure to mercury components triggers an abnormal immune response, leading to polyclonal B and T cell activation and the production of various autoantibodies such as serum IgG1 and Ig E, anti-DNA, antiphospholipid, anti-laminin-1, and antithyroglobulin, including those targeting glomerular basement membrane (GBM) components [50, 51]

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As potential inducer of HEP expression, phytoestrogens are promising dietary supplements to reduce iron overload and prevent any sequelae of iron-induced toxicities such as hyperferritinemia, coagulopathies and/or thromboembolism, which are prominent clinical manifestations in COVID-19 and PASC 94,144,494,495